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Several methods have been published for the determination of paroxetine in plasma, including reversed phase hplc with uv 8, 9 , fluorescence with or without derivatization using dansylchloride 10 12 , ms 13 15 , diode array detection 16, 17 or gas chromatography with ms detection 18 20 , and applied therapeutic drug level monitoring or bioequivalence studies.

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selegiline may cause a condition called serotonin syndrome when used together with certain mao inhibitors eg, phenelzine, rasagiline, tranylcypromine and medicines to treat depression eg, amitriptyline, doxepin, fluoxetine, fluvoxamine, nortriptyline, paroxetine, sertraline, elavil, luvox, pamelor, paxil, prozac, or zoloft .

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the long-term efficacy of paroxetine in treating obsessive compulsive disorder has been examined in three 24-week maintenance studies with relapse prevention design.

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paroxetine tablets should be administered as a single daily dose with or without food, usually in the morning.

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